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. 2012 Sep;42(9):1884-94.
doi: 10.1007/s10803-011-1431-6.

Resting-state oscillatory activity in autism spectrum disorders

Lauren Cornew  1 , Timothy P L Roberts, Lisa Blaskey, J Christopher Edgar
Affiliations

Resting-state oscillatory activity in autism spectrum disorders

Lauren Cornew et al. J Autism Dev Disord. 2012 Sep.

Abstract

Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.

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Figures

Fig. 1
Fig. 1. Source model showing the locations of the 15 regional sources and their Talairach coordinates. FpM fronto-polar midline, FL frontal left, FM frontal midline, FR frontal right, TAL temporal anterior left, TAR temporal anterior right, CL central left, CM central midline, CR central right, TPL temporal posterior left, TPR temporal posterior right, PL parential left, PM parential midline, PR parential right, OPM occipito-polar midline
Fig. 2
Fig. 2. Power spectra for the ASD (red) and TD (blue) control groups from 1–30 Hz at all 15 regional sources. Note that due to regional differences in the magnitude of oscillatory activity, the y axis scaling differs across sources (Color figure online)
Fig. 3
Fig. 3. Scatterplots showing associations between elevated alpha power in anterior temporal (left) and parietal (right) regions and symptom severity (indexed by raw SRS scores) in ASD
See this image and copyright information in PMC

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