Comment on

• A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection.

  Hecht FM, Wang L, Collier A, Little S, Markowitz M, Margolick J, Kilby JM, Daar E, Conway B, Holte S; AIEDRP Network. Hecht FM, et al. J Infect Dis. 2006 Sep 15;194(6):725-33. doi: 10.1086/506616. Epub 2006 Aug 15. J Infect Dis. 2006. PMID: 16941337 Clinical Trial.
• Rapid, real-time detection of acute HIV infection in patients in Africa.

  Fiscus SA, Pilcher CD, Miller WC, Powers KA, Hoffman IF, Price M, Chilongozi DA, Mapanje C, Krysiak R, Gama S, Martinson FE, Cohen MS; Malawi-University of North Carolina Project Acute HIV Infection Study Team. Fiscus SA, et al. J Infect Dis. 2007 Feb 1;195(3):416-24. doi: 10.1086/510755. Epub 2006 Dec 22. J Infect Dis. 2007. PMID: 17205481
• High rates of forward transmission events after acute/early HIV-1 infection.

  Brenner BG, Roger M, Routy JP, Moisi D, Ntemgwa M, Matte C, Baril JG, Thomas R, Rouleau D, Bruneau J, Leblanc R, Legault M, Tremblay C, Charest H, Wainberg MA; Quebec Primary HIV Infection Study Group. Brenner BG, et al. J Infect Dis. 2007 Apr 1;195(7):951-9. doi: 10.1086/512088. Epub 2007 Feb 16. J Infect Dis. 2007. PMID: 17330784
• HIV-1 transmission, by stage of infection.

  Hollingsworth TD, Anderson RM, Fraser C. Hollingsworth TD, et al. J Infect Dis. 2008 Sep 1;198(5):687-93. doi: 10.1086/590501. J Infect Dis. 2008. PMID: 18662132
• Public health rationale for rapid nucleic acid or p24 antigen tests for HIV.

  Pilcher CD, Christopoulos KA, Golden M. Pilcher CD, et al. J Infect Dis. 2010 Apr 15;201 Suppl 1:S7-15. doi: 10.1086/650393. J Infect Dis. 2010. PMID: 20225950 Review.
• Clinical management of acute HIV infection: best practice remains unknown.

  Bell SK, Little SJ, Rosenberg ES. Bell SK, et al. J Infect Dis. 2010 Oct 15;202 Suppl 2(Suppl 2):S278-88. doi: 10.1086/655655. J Infect Dis. 2010. PMID: 20846034 Free PMC article. Review.
• Detection of acute HIV infection: a field evaluation of the determine® HIV-1/2 Ag/Ab combo test.

  Rosenberg NE, Kamanga G, Phiri S, Nsona D, Pettifor A, Rutstein SE, Kamwendo D, Hoffman IF, Keating M, Brown LB, Ndalama B, Fiscus SA, Congdon S, Cohen MS, Miller WC. Rosenberg NE, et al. J Infect Dis. 2012 Feb 15;205(4):528-34. doi: 10.1093/infdis/jir789. Epub 2011 Dec 29. J Infect Dis. 2012. PMID: 22207651 Free PMC article.