Transforming growth factor-β1 gene +869T/C, but not +915G/C polymorphism is associated with essential hypertension in a Chinese patient cohort
- PMID: 22209986
- DOI: 10.1007/s11033-011-1427-5
Transforming growth factor-β1 gene +869T/C, but not +915G/C polymorphism is associated with essential hypertension in a Chinese patient cohort
Abstract
Many studies have suggested that transforming growth factor-β1 (TGF-β1) gene might be involved in the development of hypertension. However, results have been inconsistent. In this study, the authors performed a meta-analysis to investigate the associations of +869T/C and +915G/C polymorphisms in TGF-β1 gene with hypertension risk in Chinese. Published literature from PubMed, EMBASE, CNKI, CBM, and Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed or random-effects model. Nine studies (1,995 cases/1,840 controls) for +869T/C polymorphism and seven studies (1,547 cases/1,577 controls) for +915G/C polymorphism were included in the meta-analysis. The overall result showed that there was a statistically significant association between +869T/C polymorphism and hypertension risk (CC vs. TT: OR = 1.80, 95% CI 1.34-2.44). Similar results were found among two geographic locations and two subgroups with different sample size. However, no significant association was found for +915G/C polymorphism with the risk of hypertension (CC vs. GG: OR = 1.66, 95% CI 0.74-3.74). The meta-analysis indicated the significant association of +869T/C, but not +915G/C polymorphism with hypertension susceptibility. However, given the limited sample size, the associations warrant further investigation.
Similar articles
-
Association Between Head and Neck Cancers and Polymorphisms 869T/C, 509C/T, and 915G/C of the Transforming Growth Factor-β1 Gene: A Meta-Analysis of Case-Control Studies.Med Sci Monit. 2019 Nov 7;25:8389-8402. doi: 10.12659/MSM.917506. Med Sci Monit. 2019. PMID: 31698408 Free PMC article.
-
Lack of Association Between TGF-β1 and MDR1 Genetic Polymorphisms and Cyclosporine-Induced Gingival Overgrowth in Kidney Transplant Recipients: A Meta-analysis.Transplant Proc. 2017 Jul-Aug;49(6):1336-1343. doi: 10.1016/j.transproceed.2017.01.080. Transplant Proc. 2017. PMID: 28736004
-
Transforming growth factor β1 +869T/C gene polymorphism and essential hypertension: a meta-analysis involving 2708 participants in the Chinese population.Intern Med. 2011;50(10):1089-92. doi: 10.2169/internalmedicine.50.4967. Epub 2011 May 1. Intern Med. 2011. PMID: 21576833
-
The association of transforming growth factor beta 1 gene polymorphisms with arthritis: a systematic review and meta-analysis.Clin Exp Med. 2021 May;21(2):331-340. doi: 10.1007/s10238-020-00678-5. Epub 2021 Jan 8. Clin Exp Med. 2021. PMID: 33417083
-
No association of the TGF-β1 29T/C polymorphism with breast cancer risk in Caucasian and Asian populations: evidence from a meta-analysis involving 55,841 subjects.Asian Pac J Cancer Prev. 2014;15(20):8725-34. doi: 10.7314/apjcp.2014.15.20.8725. Asian Pac J Cancer Prev. 2014. PMID: 25374198 Review.
Cited by
-
Association of a Large Panel of Cytokine Gene Polymorphisms with Complications and Comorbidities in Type 2 Diabetes Patients.J Diabetes Res. 2015;2015:605965. doi: 10.1155/2015/605965. Epub 2015 May 6. J Diabetes Res. 2015. PMID: 26064986 Free PMC article.
-
Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children.J Hum Hypertens. 2014 Jan;28(1):32-6. doi: 10.1038/jhh.2013.50. Epub 2013 Jun 13. J Hum Hypertens. 2014. PMID: 23759979
-
Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases.Neural Regen Res. 2020 Oct;15(10):1807-1813. doi: 10.4103/1673-5374.280305. Neural Regen Res. 2020. PMID: 32246621 Free PMC article. Review.
-
The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children.Mol Biol Rep. 2013 Feb;40(2):773-8. doi: 10.1007/s11033-012-2113-y. Epub 2012 Oct 31. Mol Biol Rep. 2013. PMID: 23111453
-
The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension.J Am Soc Hypertens. 2013 Jan-Feb;7(1):68-74. doi: 10.1016/j.jash.2012.11.007. J Am Soc Hypertens. 2013. PMID: 23321405 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous