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. 2011 Jul;75(3):209-15.

Breed-specific incidence rates of canine primary bone tumors--a population based survey of dogs in Norway

Kristin P Anfinsen  1 , Tom Grotmol, Oyvind S Bruland, Thora J Jonasdottir
Affiliations

Breed-specific incidence rates of canine primary bone tumors--a population based survey of dogs in Norway

Kristin P Anfinsen et al. Can J Vet Res. 2011 Jul.

Abstract
in English, French

This is one of few published population-based studies describing breed specific rates of canine primary bone tumors. Incidence rates related to dog breeds could help clarify the impact of etiological factors such as birth weight, growth rate, and adult body weight/height on development of these tumors. The study population consisted of dogs within 4 large/giant breeds; Irish wolfhound (IW), Leonberger (LB), Newfoundland (NF), and Labrador retriever (LR), born between January 1st 1989 and December 31st 1998. Questionnaires distributed to owners of randomly selected dogs--fulfilling the criteria of breed, year of birth, and registration in the Norwegian Kennel Club--constituted the basis for this retrospective, population-based survey. Of the 3748 questionnaires received by owners, 1915 were completed, giving a response rate of 51%. Forty-three dogs had been diagnosed with primary bone tumors, based upon clinical examination and x-rays. The breeds IW and LB, with 126 and 72 cases per 10 000 dog years at risk (DYAR), respectively, had significantly higher incidence rates of primary bone tumors than NF and LR (P < 0.0001). Incidence rates for the latter were 11 and 2 cases per 10 000 DYAR, respectively. Pursuing a search for risk factors other than body size/weight is supported by the significantly different risks of developing primary bone tumors between similarly statured dogs, like NF and LB, observed in this study. Defining these breed-specific incidence rates enables subsequent case control studies, ultimately aiming to identify specific etiological factors for developing primary bone tumors.

Cette étude est l’une des rares publiées décrivant les taux de tumeur osseuse primaire canine spécifiques de race. Les taux d’incidence relatifs aux races de chien pourraient aider à clarifier l’impact de facteurs étiologiques tels que le poids à la naissance, le taux de croissance et le ratio poids corporel/taille à l’âge adulte sur le développement de ces tumeurs. La population à l’étude était composée de chiens parmi les 4 races de chien grandes/géantes; le lévrier irlandais (IW), le Leonberger (LB), le Terre-Neuve (NF) et le Labrador (LR), né entre le 1er janvier 1989 et le 31 décembre 1998. Des questionnaires distribués aux propriétaires de chiens sélectionnés au hasard — répondant aux critères de race, année de naissance, et enregistrement au Club Canin Norvégien — ont constitué les éléments pour cette étude rétrospective. Sur les 3748 questionnaires soumis aux propriétaires, 1915 ont été complétés, donnant un taux de réponse de 51 %. Quarante-trois chiens ont été diagnostiqués avec des tumeurs osseuses primaires, en fonction de l’examen clinique et des examens radiologiques. Les races IW et LB, avec respectivement 126 et 72 cas par 10 000 années-chien à risque (DYAR), avaient des taux d’incidence de tumeurs osseuses primaires significativement plus élevés que les races NF et LR (P < 0,0001). Les taux d’incidence pour ces derniers étaient respectivement de 11 et 2 cas par 10 000 DYAR. La recherche de facteurs de risque autres que le ratio taille/poids est supportée par les risques significativement différents observés dans la présente étude de développer des tumeurs osseuses primaires parmi les chiens de statures similaires tels les NF et LB. La définition de ces taux d’incidence spécifiques de race permettra des études cas-témoins ultérieures visant à identifier les facteurs étiologiques spécifiques pour le développement des tumeurs osseuses primaires.

(Traduit par Docteur Serge Messier)

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Figures

Figure 1
Figure 1
Age at time of diagnosis of primary bone tumors in 4 breeds of dogs: Leonberger (LB), Irish wolfhound (IW), Newfoundland (NF), and Labrador retriever (LR), born between 1989 and 1998, and registered in the Norwegian Kennel Club.
Figure 2
Figure 2
Anatomical location of primary bone tumors among 4 breeds of dogs born between 1989 and 1998, and registered in the Norwegian Kennel Club.
See this image and copyright information in PMC

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References

    1. Brodey RS, Sauer RM, Medway W. Canine bone neoplasms. J Am Vet Med Assoc. 1963;143:471–495. - PubMed
    1. Bruland OS, Bauer H, Alvegaard T, Smeland S. Treatment of osteosarcoma. The Scandinavian Sarcoma Group Experience. In: Jaffe N, Bruland OS, Bielack S, editors. Pediatric and Adolescent Osteosarcoma. 1st ed. New York: Springer; 2010. pp. 309–318. - PubMed
    1. Withrow SJ, Powers BE, Straw RC, Wilkins RM. Comparative aspects of osteosarcoma. Dog versus man. Clin Orthop Relat Res. 1991;270:159–568. - PubMed
    1. Bruland OS, Pihl A. On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy. Eur J Cancer. 1997;33:1725–1731. - PubMed
    1. Bacci G, Rocca M, Salone M, et al. High grade osteosarcoma of the extremities with lung metastases at presentation: Treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions. J Surg Oncol. 2008;98:415–420. - PubMed

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