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. 2012 Jan;4(1):52-4.
doi: 10.4168/aair.2012.4.1.52. Epub 2011 Nov 10.

Meloxicam-induced rhabdomyolysis in the context of an acute ross river viral infection

Mahmood Al Kindi  1 , Vidya Limaye, Pravin Hissaria
Affiliations

Meloxicam-induced rhabdomyolysis in the context of an acute ross river viral infection

Mahmood Al Kindi et al. Allergy Asthma Immunol Res. 2012 Jan.

Abstract

Acute rhabdomyolysis is a clinical and laboratory syndrome resulting from the breakdown of skeletal muscle, with the release of intracellular contents into the circulatory system, which can cause potentially lethal complications. Here, we present the case of a patient who developed acute rhabdomyolysis after consumption of meloxicam for jaw pain and experienced generalized myalgias in the context of an acute febrile illness with generalized urticaria. Further investigation indicated elevated muscle enzymes and acute renal failure. Serological analysis revealed that the patient was positive for Ross River virus (RRV) IgM. Genetic studies to detect CYP2C9 polymorphisms were negative. Meloxicam was discontinued. He responded to conservative measures within 2 weeks. Oral aspirin challenge was negative, suggesting a drug-specific effect of meloxicam rather than a class effect. Our case indicates a causative role for meloxicam and/or acute RRV in rhabdomyolysis.

Keywords: RRV infection; meloxicam; rhabdomyolysis.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

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