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. 2012 Jan-Feb;21(1):5-10.
doi: 10.1111/j.1521-0391.2011.00195.x. Epub 2011 Dec 15.

Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals

Albert J Arias  1 , Grace Chan, Joel Gelernter, Lindsay Farrer, Henry R Kranzler
Affiliations

Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals

Albert J Arias et al. Am J Addict. 2012 Jan-Feb.

Abstract

Completed suicide and nonfatal suicide-related outcomes (SROs), such as suicidal ideation and attempts, are heritable. A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide. We examined the association of three OPRM1 single nucleotide polymorphisms (SNPs) (rs1799971, rs609148, and rs648893) with SRO in 426 European Americans, using GEE logistic regression analysis to examine the association of a lifetime history of SRO. There was no allelic association with the SRO phenotypes. A larger sample may be needed to identify risk variants that convey SRO risk. OPRM1 may not be important in the risk of SRO.

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Conflict of interest statement

Declaration of Interests: Dr. Kranzler has had consulting arrangements with the following pharmaceutical companies: Alkermes, Lundbeck, Gilead, GlaxoSmithKline, and Roche. Eli Lilly, Janssen, Schering Plough, Lundbeck, Alkermes, GlaxoSmithKline, Abbott, and Johnson & Johnson provide support to the Alcohol Clinical Trials Initiative (ACTIVE), from which he also receives support. He reports research support from Merck.

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

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