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. 1990 Nov;147(11):1471-5.
doi: 10.1176/ajp.147.11.1471.

Influence of patient-related variables on clozapine plasma levels

C Haring  1 , W W Fleischhacker, P Schett, C Humpel, C Barnas, A Saria
Affiliations

Influence of patient-related variables on clozapine plasma levels

C Haring et al. Am J Psychiatry. 1990 Nov.

Abstract

The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.

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