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Comparative Study
. 2011 Dec:1245:11-3.
doi: 10.1111/j.1749-6632.2011.06342.x.

Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations

Nick Andrews  1 , Sinead Harper, Yasmin Issop, Andrew S C Rice
Affiliations
Comparative Study

Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations

Nick Andrews et al. Ann N Y Acad Sci. 2011 Dec.

Abstract

We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e.g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.

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