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. 2012 Mar;22(3):443-6.
doi: 10.1038/cr.2012.5. Epub 2012 Jan 3.

Breathless cancer cells get fat on glutamine

Dimitrios Anastasiou  1 , Lewis C Cantley
Affiliations

Breathless cancer cells get fat on glutamine

Dimitrios Anastasiou et al. Cell Res. 2012 Mar.
No abstract available

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Figures

Figure 1
Figure 1
A metabolic switch in carbon source for lipid synthesis. (A) Under conditions when mitochondrial respiration is fully functional, glucose is the major source of carbons for acetyl-CoA to synthesize lipids. The yellow block arrow indicates the route of carbons from glucose to lipids. The blue block arrow indicates oxidative glutamine metabolism (anaplerosis). The green block arrow shows the metabolic pathway of citrate generated from glucose-derived acetyl-CoA and glutamine-derived oxaloacetate. (B) Under conditions where HIF is stabilized (such as hypoxia or upon VHL deletion) or when mitochondrial respiration is limited, glutamine predominantly provides carbons for lipogenic acetyl-CoA either via cytoplasmic IDH1 (yellow block arrow) or mitochondrial IDH2 (orange block arrow). This pathway is referred to as reductive glutamine metabolism. The exact route of glutamine to acetyl-CoA most likely depends on the extend of mitochondrial respiration. In red and green are processes or compounds that promote or prevent reductive glutamine metabolism, respectively. Key enzymes are represented in blue boxes and their name abbreviations are described in the text.
See this image and copyright information in PMC

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