Review
doi: 10.1111/j.1349-7006.2011.02195.x.
Epub 2012 Jan 29.
Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding
Affiliations
- PMID: 22212856
- PMCID: PMC7659190
- DOI: 10.1111/j.1349-7006.2011.02195.x
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Review
Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding
Cancer Sci.
2012 Apr.
Abstract
The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?
© 2011 Japanese Cancer Association.
Figures
Steps in the metastatic process. (a) primary tumor, (b) angiogenesis in primary tumor, (c) intravasation, (d) migration and extravasation, (e) colonization of new organ and (f) angiogenesis and growth of new tumor.
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