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Review
. 2012 Apr;103(4):626-31.
doi: 10.1111/j.1349-7006.2011.02195.x. Epub 2012 Jan 29.

Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding

Lucy Mathot  1 , Johan Stenninger
Affiliations
Review

Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding

Lucy Mathot et al. Cancer Sci. 2012 Apr.

Abstract

The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?

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Figures

Figure 1
Figure 1
Steps in the metastatic process. (a) primary tumor, (b) angiogenesis in primary tumor, (c) intravasation, (d) migration and extravasation, (e) colonization of new organ and (f) angiogenesis and growth of new tumor.
See this image and copyright information in PMC

References

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