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. 2012 Apr;138(4):627-35.
doi: 10.1007/s00432-011-1142-6. Epub 2012 Jan 4.

Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma

Songlin Piao  1 , Shu Zhao, Fulin Guo, Jie Xue, Guodong Yao, Zhili Wei, Qi Huang, Yao Sun, Bin Zhang
Affiliations

Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma

Songlin Piao et al. J Cancer Res Clin Oncol. 2012 Apr.

Abstract

Purpose: The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.

Methods: We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC.

Results: Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (P (CD147) = 0.031; P (MMP-9) = 0.020) and overall survival (OS) (P (CD147) = 0.044; P (MMP-9) = 0.013).

Conclusion: CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.

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Conflict of interest statement

All authors declared that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Immunohistochemistry for CD147 and MMP-9 in the specimens. Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. High expression of CD147 (n = 16) and MMP-9 (n = 18) was observed, respectively. The predominant pattern of CD147 and MMP-9 staining was cytoplasmic and the cell membrane. All non-cancerous salivary tissue (n = 20) was negative expression for CD147 and MMP-9
Fig. 2
Fig. 2
A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues (n = 35, r = 0.736, P < 0.001)
Fig. 3
Fig. 3
Overall survival of all salivary duct carcinoma patients
Fig. 4
Fig. 4
Kaplan–Meier analysis showed poorer progression-free survival (P = 0.031) and overall survival (P = 0.044) of patients with high expression of CD147
Fig. 5
Fig. 5
Kaplan–Meier analysis showed poorer progression-free survival (P = 0.020) and overall survival (P = 0.013) of patients with high expression of MMP-9
See this image and copyright information in PMC

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