Management of dyslipidemia in HIV-infected patients
- PMID: 22216062
- PMCID: PMC3249059
- DOI: 10.2217/clp.11.25
Management of dyslipidemia in HIV-infected patients
Abstract
Antiretroviral therapy has dramatically increased survival for HIV-infected individuals. As this population lives longer, coronary heart disease has become an important comorbid condition. Dyslipidemia in HIV-infected individuals is a complex condition, with multiple contributing factors including the HIV virus itself, individual genetic characteristics and antiretroviral therapy-induced metabolic changes. Effective management of dyslipidemia in this population is essential to reduce cardiovascular risk but presents multiple challenges due to interactions between antiretroviral therapy agents and lipid-lowering medications.
References
Bibliography
-
- Friis-Moller N, Reiss P, Sabin C, et al. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007;356(17):1723–1735. - PubMed
-
- Grunfeld C, Pang M, Doerrler W, Shigenaga JK, Jensen P, Feingold KR. Lipids, lipoproteins, triglyceride clearance and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. J Clin Endocr Metabo. 1992;74(5):1045–1052. - PubMed
-
- Klein DHL, Quesenberry C, Silverberg M, Horberg M, Sidney S. Hospitalizations for CHD and MI among northern California HIV+ and HIV− men: changes in practice and Framingham risk scores. Presented at: 13th Conference on Retroviruses and Opportunistic Infections; Denver, CO, USA. 5–8 February 2006.
-
- Obel N, Thomsen H, Kronborg G, et al. Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study. Clin Infect Dis. 2007;44(12):1625–1631. - PubMed
Website
-
- National Cholesterol Education Program. Third report on the expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). 2002 (Update 2004) [Accessed 29 November 2010]; www.nhlbi.nih.gov/guidelines/cholesterol/atp3full.pdf.
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials