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Case Reports
. 1976 Dec;3(6):1045-51.
doi: 10.1111/j.1365-2125.1976.tb00356.x.

Altered distribution of digoxin in renal failure--a cause of digoxin toxicity?

J K Aronson  1 , D G Grahame-Smith
Affiliations
Case Reports

Altered distribution of digoxin in renal failure--a cause of digoxin toxicity?

J K Aronson et al. Br J Clin Pharmacol. 1976 Dec.

Abstract

Three cases are described in which renal failure was accompanied by a lowered apparent volume of distribution of digoxin. In two cases this resulted in frank digoxin toxicity and in one equivocal toxicity. In all three cases digoxin plasma levels were greater than 2 ng/ml. The possible causes of the abnormal distribution of digoxin in renal failure are discussed. Recommendations are outlined for the use of digoxin in patients with renal failure aimed at circumventing the problem raised by a lowered apparent volume of distribution of the drug.

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References

    1. Circulation. 1969 Oct;40(4):555-61 - PubMed
    1. Br Med J. 1974 Dec 28;4(5947):733-6 - PubMed
    1. J Clin Pharmacol. 1974 Jul;14(7):329-38 - PubMed
    1. J Pharmacol Exp Ther. 1966 Jun;152(3):372-82 - PubMed
    1. J Pharmacol Exp Ther. 1964 Aug;145:203-9 - PubMed

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