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Comparative Study
. 2012 Jun;160(6):911-7.
doi: 10.1016/j.jpeds.2011.11.026. Epub 2012 Jan 3.

Health-related quality of life in adolescents with or at risk for type 2 diabetes mellitus

Erinn T Rhodes  1 , Michael I Goran, Tracy A Lieu, Robert H Lustig, Lisa A Prosser, Thomas J Songer, Marc J Weigensberg, Ruth S Weinstock, Tessa Gonzalez, Kaitlin Rawluk, Roula M Zoghbi, David S Ludwig, Lori M Laffel
Affiliations
Comparative Study

Health-related quality of life in adolescents with or at risk for type 2 diabetes mellitus

Erinn T Rhodes et al. J Pediatr. 2012 Jun.

Abstract

Objective: To evaluate how adolescents with or at risk for type 2 diabetes mellitus (T2DM) and their parent/guardians (parents) perceive adolescents' health-related quality of life.

Study design: We interviewed overweight/obese, 12- to 18-year-old youth with T2DM, prediabetes, or insulin resistance and one parent from 5 US sites. Assessments included Pediatric Quality of Life Inventory (PedsQL), Health Utilities Index, family conflict, and diabetes burden.

Results: In 108 adolescents, diagnoses included 40.7% with T2DM, 25.0% with prediabetes, and 34.3% with insulin resistance. PedsQL summary score (SS) was higher in adolescents than parents (P=.02). Parents rated physical functioning lower than adolescents (P<.0001), but there were no differences in psychosocial health. Adolescent PedsQL SS did not differ with diagnosis, but was inversely associated with adolescent body mass index z-score (P=.0004) and family conflict (P<.0001) and associated with race/ethnicity (P<.0001). Number of adolescent co-morbidities (P=.007) and burden of diabetes care (P<.05) were inversely associated with parent PedsQL SS. There were no differences in the Health Utilities Index-Mark 3 multi-attribute utility score.

Conclusions: Parents perceive their adolescents' physical functioning as more impaired than adolescents themselves. Contextual factors including severity of obesity, race/ethnicity, family conflict, and burden of diabetes care influence health-related quality of life. Family-based approaches to treatment and prevention of T2DM may benefit from increased attention to the biopsychosocial context.

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