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. 1990 Aug;34(8):1501-4.
doi: 10.1128/AAC.34.8.1501.

Novel beta-lactamase from Capnocytophaga sp

J E Foweraker  1 , P M Hawkey, J Heritage, H W Van Landuyt
Affiliations

Novel beta-lactamase from Capnocytophaga sp

J E Foweraker et al. Antimicrob Agents Chemother. 1990 Aug.

Abstract

A novel beta-lactamase activity which confers resistance to expanded-spectrum cephalosporins and penicillins has been found in strain IC 5/21 of Capnocytophaga spp. Enzyme activity migrated at a molecular size of 38,000 daltons and at an isoelectric point of 3.6, with a minor band at 4.1. Kinetic studies suggested that it belonged to Richmond and Sykes beta-lactamase class 1c. Isoelectric focusing could be achieved only if a nonionic detergent was added to the gel, suggesting the presence of a hydrophobic enzyme akin to a membrane-bound beta-lactamase of gram-positive bacteria. The location of the gene coding for this beta-lactamase is not yet known.

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