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Comparative Study
. 1990 Aug;34(8):1619-21.
doi: 10.1128/AAC.34.8.1619.

Comparison of cilofungin and amphotericin B for therapy of murine candidiasis

K R Smith  1 , K M Lank, C G Cobbs, G A Cloud, W E Dismukes
Affiliations
Comparative Study

Comparison of cilofungin and amphotericin B for therapy of murine candidiasis

K R Smith et al. Antimicrob Agents Chemother. 1990 Aug.

Abstract

We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P less than 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).

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