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Editorial

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease

Victor L Villemagne et al. Eur J Nucl Med Mol Imaging. 2012 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
“Development of amyloid deposits in 2,661 nonselected autopsy cases. The first line displays the frequency of cases devoid of changes in relation to the total number of cases in the various age categories. The second, third, and fourth lines are similarly designed, and show the evolution of the AD-related changes. The dark areas of the columns refer to subgroups showing the presence of neurofibrillary changes.” (reproduced with permission from Neurobiol Aging, [22])
Fig. 2
Fig. 2
Correlations of the in vivo PiB distribution volume ratio (DVR) values with postmortem quantifications of [3H]PiB binding (E) and total insoluble Aβ (Aβ1-40 + Aβ1-42) peptide levels (F) in 19 brain regions from fresh-frozen tissue from the right hemisphere of the same Alzheimer’s disease subject. (reproduced with permission from Brain, [36])
Fig. 3
Fig. 3
Comparison of the regional distribution of PiB retention in a presenilin-1 mutation carrier (left) and a sporadic case of AD (right). The MRI is shown in gray and PiB retention is overlaid in a hot metal scale on transaxial (top), sagittal (middle), and coronal images (bottom)
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