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. 2012 Dec;21(10):1837-45.
doi: 10.1007/s11136-011-0100-8. Epub 2012 Jan 5.

Health-related quality of life of Spanish children with cystic fibrosis

Iris F Groeneveld  1 , Elena S Sosa, Margarita Pérez, Carmen Fiuza-Luces, Laura Gonzalez-Saiz, Cristian Gallardo, Luis M López-Mojares, Jonatan R Ruiz, Alejandro Lucia
Affiliations

Health-related quality of life of Spanish children with cystic fibrosis

Iris F Groeneveld et al. Qual Life Res. 2012 Dec.

Abstract

Purpose: To investigate (1) the contributions of sex, age, nutritional status- and physical-fitness-related variables on health-related quality of life (HRQOL) in Spanish children with cystic fibrosis, and (2) the agreement on HRQOL between children and their parents.

Methods: In 28 children aged 6-17 years, body mass index percentile, percentage body fat, physical activity, pulmonary function, cardiorespiratory fitness, functional mobility, and dynamic muscle strength were determined using objective measures. HRQOL was measured using the revised version of the cystic fibrosis questionnaire. Simple and multiple linear regression analyses were performed to determine the variables associated with HRQOL. To assess the agreement on HRQOL between children and parents, intra-class correlation coefficients (ICCs) were calculated.

Results: Girls reported worse emotional functioning, a higher treatment burden, and more respiratory problems than boys. Greater functional mobility appeared associated with a less favourable body image and more eating disturbances. Agreement on HRQOL between children and parents was good to excellent, except for the domain of treatment burden.

Conclusions: Sex and age were stronger predictors of HRQOL than nutritional status- or physical-fitness-related variables. Children reported a lower treatment burden than their parents perceived them to have.

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Figures

Fig. 1
Fig. 1
Median scores on eight health-related quality of life domains of boys (n = 14) and girls (n = 14) with cystic fibrosis aged 6–17. Black bar: boys. Grey bar: girls
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