Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Nov;67(Pt 11):o2881-2.
doi: 10.1107/S160053681104061X. Epub 2011 Oct 8.

14-Hy-droxy-11-[(E)-4-meth-oxy-benzyl-idene]-8-(4-meth-oxy-phen-yl)-5-thia-3,13-diaza-hepta-cyclo-[13.7.1.1.0.0.0.0]tetra-cosa-1(22),15(23),16,18,20-pentaen-10-one

Raju Suresh Kumar, Hasnah Osman, A S Abdul Rahim, Madhukar Hemamalini, Hoong-Kun Fun

14-Hy-droxy-11-[(E)-4-meth-oxy-benzyl-idene]-8-(4-meth-oxy-phen-yl)-5-thia-3,13-diaza-hepta-cyclo-[13.7.1.1.0.0.0.0]tetra-cosa-1(22),15(23),16,18,20-pentaen-10-one

Raju Suresh Kumar et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Nov.

Abstract

In the title compound, C(36)H(32)N(2)O(4)S, the piperidine ring adopts a chair conformation, while the five-membered pyrrolidine (with a C atom as the flap atom) and thia-zolidine (with the S atom as the flap atom) rings adopt envelope conformations. The naphthalene ring system makes dihedral angles of 18.82 (5) and 40.92 (5)° with the two meth-oxy-substituted benzene rings. In the crystal, centrosymmetrically-related mol-ecules are linked into dimers via pairs of C-H⋯O and C-H⋯N hydrogen bonds. An intra-molecular O-H⋯N hydrogen bond is also observed. The crystal structure is further stabilized by C-H⋯π inter-actions.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
The asymmetric unit of the title compound, showing 30% probability displacement ellipsoids.
Fig. 2.
Fig. 2.
The crystal packing of the title compound (I). H atoms not involved in hydrogen bonding are omitted.
See this image and copyright information in PMC

References

    1. Aicher, T. D., Balkan, B., Bell, P. A., Brand, L. J., Cheon, S. H., Deems, R. O., Fell, J. B., Fillers, W. S., Fraser, J. D., Gao, J., Knorr, D. C., Kahle, G. G., Leone, C. L., Nadelson, J., Simpson, R. & Smith, H. C. (1998). J. Med. Chem. 41, 4556–4566. - PubMed
    1. Bruker (2009). APEX2, SAINT and SADABS Bruker AXS Inc., Madison, Wisconsin, USA.
    1. Cosier, J. & Glazer, A. M. (1986). J. Appl. Cryst. 19, 105–107.
    1. Cremer, D. & Pople, J. A. (1975). J. Am. Chem. Soc. 97, 1354–1358.
    1. Lalezari, I. & Schwartz, E. L. (1988). J. Med. Chem. 31, 1427–1429. - PubMed