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. 2012:2012:289852.
doi: 10.1155/2012/289852. Epub 2011 Dec 19.

The evolving paradigm in the management of intracranial atherosclerotic disease

Ali K Ozturk  1 , Ketan R Bulsara
Affiliations

The evolving paradigm in the management of intracranial atherosclerotic disease

Ali K Ozturk et al. Int J Vasc Med. 2012.

Abstract

Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke worldwide and represents a significant health problem. The pathogenesis and natural history of ICAD are poorly understood, and rigorous treatment paradigms do not exist as they do for extracranial atherosclerosis. Currently, the best treatment for ICAD remains aspirin therapy, but many patients who are placed on aspirin continue to experience recurrent strokes. As microsurgical and endovascular techniques continue to evolve, the role of extracranial to intracranial bypass operations and stenting are increasingly being reconsidered. We performed a PubMed review of the English literature with a particular focus on treatment options for ICAD and present evidence-based data for the role of surgery and stenting in ICAD against medical therapy alone.

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Figures

Figure 1
Figure 1
Schematic of STA-MCA bypass.
Figure 2
Figure 2
Stent and balloon catheter commonly used in ICAD.
See this image and copyright information in PMC

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