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Case Reports
. 2012 Jan;63(1):47-51.
doi: 10.1007/s00105-011-2277-8.

[Generalized erythrosquamous dermatosis]

[Article in German]
T Weberschock  1 , I Hausser, P Gholam, M Hartmann
Affiliations
Case Reports

[Generalized erythrosquamous dermatosis]

[Article in German]
T Weberschock et al. Hautarzt. 2012 Jan.

Abstract

A 21-year-old man presented with generalized erythema, erosions and hyperkeratoses since birth. Histology revealed epidermolytic hyperkeratosis with degeneration of the upper epidermis and perinuclear deposits of abnormal keratin aggregations. Epidermolytic ichthyosis was diagnosed. This congenital Ichthyosis occurs due to mutations of keratin 1 or 10 genes that leads to defects of intra- and intercellular structural integrity in the spinous and granular layers with compensatory hyperkeratosis. After childhood, life expectancy is normal but lifelong therapeutic and skin care measures are required.

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References

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