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Review
. 2012 Feb;139(3):443-8.
doi: 10.1242/dev.050054.

Cilia in vertebrate development and disease

Edwin C Oh  1 , Nicholas Katsanis
Affiliations
Review

Cilia in vertebrate development and disease

Edwin C Oh et al. Development. 2012 Feb.

Abstract

Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.

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