Krüppel-like factors in lymphocyte biology

Abstract

The Krüppel-like factor family of transcription factors plays an important role in differentiation, function, and homeostasis of many cell types. While their role in lymphocytes is still being determined, it is clear that these factors influence processes as varied as lymphocyte quiescence, trafficking, differentiation, and function. This review will present an overview of how these factors operate and coordinate with each other in lymphocyte regulation.

Figure 1. KLFs regulate numerous processes in lymphocytes

The figure illustrates known roles of KLFs in various aspects of lymphocyte differentiation and function. The KLFs written in green promote the indicated activity, while KLFs indicted by red text inhibit the response. Note that KLFs expressed in the same cell may cooperate or antagonize with each other. The role of KLF2 and KLF4 in control of T cell quiescence is shown with a dotted line, since the physiological significance of this pathway is unclear. The capacity of KLF3 to oppose KLF2 in control of some lymphocyte trafficking molecules has been shown in B cells but not yet addressed in T cells, hence KLF3 is written in parenthesis. Details of individual functions are provided in the text.