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. 2012 Feb 15;205(4):535-9.
doi: 10.1093/infdis/jir788. Epub 2012 Jan 5.

Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke

S W Worm  1 , D A Kamara, P Reiss, E Fontas, S De Wit, W El-Sadr, A D'Arminio Monforte, M Law, A Phillips, L Ryom, F Dabis, R Weber, C Sabin, J D Lundgren; D:A:D Study Group
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Free article

Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke

S W Worm et al. J Infect Dis. .
Free article

Abstract

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

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