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. 2011 Dec;82(12):126106.
doi: 10.1063/1.3665933.

Note: Integration of trapped ion mobility spectrometry with mass spectrometry

F A Fernandez-Lima  1 , D A Kaplan, M A Park
Affiliations

Note: Integration of trapped ion mobility spectrometry with mass spectrometry

F A Fernandez-Lima et al. Rev Sci Instrum. 2011 Dec.

Abstract

The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIMS mobility resolution depends on the analysis scan speed and the bath gas velocity, with the unique advantage that the IMS separation can be easily tuned from high speed (~25 ms) for rapid analysis to slower scans for higher mobility resolution (R > 80).

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Figures

Figure 1
Figure 1
(a) TIMS-MS instrument schematics. (b) Mobility resolution dependence on the ramp time and the inlet pressure P1. (c) Mobility resolution dependence on the ramp time for a Tunemix mixture (m/z = 322, 622, and 922). (d) Relative ion signal dependence on the ramp time. (e) Total IMS time dependence on the axial field applied on the ion cooling cell.
Figure 2
Figure 2
Relative ion signal variation for a Tunemix sample (m/z = 322, 622, and 922) as a function of (a) RF amplitude and (b) fill time.
See this image and copyright information in PMC

References

    1. Fernandez-Lima F. A., Kaplan D. A., Suetering J., and Park M. A., Int. J. Ion Mobility Spectrosc. 14, 93 (2011), and references herein10.1007/s12127-011-0067-8 - DOI - PMC - PubMed
    1. Flanagan L. A., U. S. patent 5872357, Hewlett-Packard Company, Palo Alto, CA, USA, February 16, 1999, p. 19.

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