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. 1990 Oct;33(10):1554-9.
doi: 10.1002/art.1780331013.

Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin

Y Naparstek  1 , A Ben-Yehuda, M P Madaio, R Bar-Tana, L Schuger, G Pizov, Z V Neeman, I R Cohen
Affiliations

Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin

Y Naparstek et al. Arthritis Rheum. 1990 Oct.

Abstract

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low-dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

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