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Comment
. 2012 Jan 4;15(1):1-2.
doi: 10.1016/j.cmet.2011.12.007.

Treating obesity like a tumor

Randy J Seeley  1
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Free article
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Treating obesity like a tumor

Randy J Seeley. Cell Metab. .
Free article

Abstract

Expanding adipose tissue in obesity requires a great deal of angiogenesis to support increasing volumes of tissue. A growing body of evidence indicates that inhibiting these blood vessels can result in substantial weight loss, and now this has been demonstrated in nonhuman primates.

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  • Adipose tissue mass can be regulated through the vasculature.
    Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ. Rupnick MA, et al. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10730-5. doi: 10.1073/pnas.162349799. Epub 2002 Jul 29. Proc Natl Acad Sci U S A. 2002. PMID: 12149466 Free PMC article.

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