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. 2012 Jan 4;15(1):4-5.
doi: 10.1016/j.cmet.2011.12.011.

Power surge: supporting cells "fuel" cancer cell mitochondria

Ubaldo E Martinez-Outschoorn  1 , Federica Sotgia, Michael P Lisanti
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Power surge: supporting cells "fuel" cancer cell mitochondria

Ubaldo E Martinez-Outschoorn et al. Cell Metab. .
Free article

Abstract

An emerging paradigm in tumor metabolism is that catabolism in host cells "fuels" the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.

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