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Comment
. 2012 Mar 1;52(5):838-40.
doi: 10.1016/j.freeradbiomed.2011.12.014. Epub 2011 Dec 22.

Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant

Tanecia Mitchell  1 , Victor Darley-Usmar
Affiliations
Comment

Metabolic syndrome and mitochondrial dysfunction: insights from preclinical studies with a mitochondrially targeted antioxidant

Tanecia Mitchell et al. Free Radic Biol Med. .
No abstract available

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Figures

Figure 1
Figure 1
Genetic and lifestyle factors contribute to the development of metabolic syndrome. Obesity is the most common feature of metabolic syndrome and can occur with one or more of the following risk factors: high cholesterol, insulin resistance, hyperglycemia, hypertension, and high triglycerides. Reactive oxygen species (ROS) generation and mitochondrial signaling is increased during this time and may the initiate a vicious cycle activating an inflammatory response and exacerbating bioenergetic dysfunction. Ultimately this contributes to diabetes, cardiovascular diseases, and steatosis.
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