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. 2012 Feb 1;59(2):121-5.
doi: 10.1097/QAI.0b013e3182392ebe.

Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection

Alessandra Pontillo  1 , Telma M Oshiro, Martina Girardelli, Anselmo J Kamada, Sergio Crovella, Alberto J S Duarte
Affiliations

Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection

Alessandra Pontillo et al. J Acquir Immune Defic Syndr. .

Abstract

The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.

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