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Review
. 2012 Mar;7(2):99-105.
doi: 10.1097/COH.0b013e32834f5cf2.

HIV treatment as prevention and HPTN 052

Myron S Cohen  1 , Marybeth McCauley, Theresa R Gamble
Affiliations
Review

HIV treatment as prevention and HPTN 052

Myron S Cohen et al. Curr Opin HIV AIDS. 2012 Mar.

Abstract

Purpose of review: This review summarizes the development and implementation of a large clinical trial, HIV Prevention Trials Network (HPTN) 052, whose initial results were recently presented and published.

Recent findings: A randomized, clinical trial demonstrated that antiretroviral therapy reduces the sexual transmission of HIV in HIV-serodiscordant couples by more than 96%. The logistical challenges in preparing for and conducting such a trial were considerable.

Summary: HPTN 052 required many years of preparation, considerable collaboration between National Institute of Health and six pharmaceutical companies, and careful ongoing consideration of a large number of ethical issues. HPTN 052 revealed the magnitude of benefit when using antiretroviral therapy to prevent the transmission of HIV, and served as proof of a concept. The results have proven central to the development of new global HIV-prevention efforts.

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Figures

Figure 1
Figure 1
HPTN 052 Study Design
See this image and copyright information in PMC

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