Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Mar;30(3):567-73.
doi: 10.1097/HJH.0b013e32834f6f3f.

Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity

Damien Mandry  1 , Romain Eschalier, Anna Kearney-Schwartz, Patrick Rossignol, Laure Joly, Wassila Djaballah, Philip Böhme, Jean M Escanyé, Pierre A Vuissoz, Renaud Fay, Faïez Zannad, Pierre Y Marie
Affiliations

Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity

Damien Mandry et al. J Hypertens. 2012 Mar.

Abstract

Objectives: To determine, using a comprehensive MRI investigation, prevalence and vascular correlates of early left-ventricular concentric remodeling in middle-aged patients with abdominal obesity. Left-ventricular and vascular remodeling are commonly associated with hypertension, but little is known for abdominal obesity patients, a population with definite increase in cardiovascular risk and high rates of further developments of hypertension and of the metabolic syndrome.

Methods: Seventy middle-aged abdominal obesity patients (56 ± 5 years, 49% women, 69% with body mass index > 30 kg/m), who had no additional cardiovascular risk factor except for untreated stage 1 hypertension (16%), and 40 controls underwent MRI for detecting concentric remodeling (increase in left-ventricular mass/end-diastolic volume ratio) and identifying potential determinants, including arterial compliance indexes [aortic pulse wave velocity and total arterial compliance (TAC)] and total peripheral vascular resistances (TPVRs).

Results: Twenty abdominal obesity patients (29%) had concentric remodeling (concentric remodeling+), whereas 50 did not (concentric remodeling-). Concentric remodeling+ patients were mostly men (85%), they frequently had stage 1 hypertension (45%) and few had left-ventricular hypertrophy (20%). When adjusted for sex, there was a step-by-step decline in TAC between controls (mean ± SEM: 2.10 ± 0.06 ml/mmHg), concentric remodeling- (1.82 ± 0.06 ml/mmHg) and concentric remodeling+ (1.42 ± 0.09 ml/mmHg, P < 0.005 for inter-group comparisons) and TPVRs were lower than controls for concentric remodeling- (14.7 ± 0.5 vs. 16.8 ± 0.5 ml/mmHg, P = 0.005) but not for concentric remodeling+ (17.5 ± 0.7 mmHg/min per l).

Conclusions: Concentric remodeling is frequently documented by MRI in the middle-aged men with abdominal obesity and in association with a decrease in TAC no longer counter-balanced by a decrease in TPVR, suggesting a remodeling from proximal to peripheral vasculature.

PubMed Disclaimer

Publication types