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. 2012 Jan 7;18(1):44-8.
doi: 10.3748/wjg.v18.i1.44.

Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test

Masaaki Kodama  1 , Kazunari Murakami, Tadayoshi Okimoto, Yoshihiro Fukuda, Tadashi Shimoyama, Masumi Okuda, Chieko Kato, Intetsu Kobayashi, Toshio Fujioka
Affiliations

Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test

Masaaki Kodama et al. World J Gastroenterol. .

Abstract

Aim: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay.

Methods: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration.

Results: Using the UBT as the standard, the sensitivity, specificity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were significantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A(450/630)) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099).

Conclusion: The stool antigen test was equally sensitive to the UBT, making it a useful and reliable diagnostic method, even during PPI administration.

Keywords: Helicobacter pylori; Proton pump inhibitor; Stool antigen test; Urea breath test.

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Figures

Figure 1
Figure 1
Urea breath test results (13CO2/12CO2 ratios) before and after proton pump inhibitor treatment. UBT results in all 28 patients were not altered by PPI treatment (P = 0.068). However, among patients treated for ≥ 4 wk, UBT results decreased significantly after PPI treatment (P = 0.048). UBT: Urea breath test; PPI: Proton pump inhibitor.
Figure 2
Figure 2
Stool antigen test results (A450/A630 ratios) before and after proton pump inhibitor treatment. PPI treatment did not significantly alter stool antigen test results, both in all patients (P = 0.989) and in those treated for ≥ 4 wk (P = 0.099). PPI: Proton pump inhibitor.
See this image and copyright information in PMC

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