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Randomized Controlled Trial
. 2012 Jan-Feb;10(1):15-22.
doi: 10.1370/afm.1344.

Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial

Hillary R Bogner  1 , Knashawn H Morales, Heather F de Vries, Anne R Cappola
Affiliations
Randomized Controlled Trial

Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial

Hillary R Bogner et al. Ann Fam Med. 2012 Jan-Feb.

Abstract

Purpose: Depression commonly accompanies diabetes, resulting in reduced adherence to medications and increased risk for morbidity and mortality. The objective of this study was to examine whether a simple, brief integrated approach to depression and type 2 diabetes mellitus (type 2 diabetes) treatment improved adherence to oral hypoglycemic agents and antidepressant medications, glycemic control, and depression among primary care patients.

Methods: We undertook a randomized controlled trial conducted from April 2010 through April 2011 of 180 patients prescribed pharmacotherapy for type 2 diabetes and depression in primary care. Patients were randomly assigned to an integrated care intervention or usual care. Integrated care managers collaborated with physicians to offer education and guideline-based treatment recommendations and to monitor adherence and clinical status. Adherence was assessed using the Medication Event Monitoring System (MEMS). We used glycated hemoglobin (HbA(1c)) assays to measure glycemic control and the 9-item Patient Health Questionnaire (PHQ-9) to assess depression.

Results: Intervention and usual care groups did not differ statistically on baseline measures. Patients who received the intervention were more likely to achieve HbA(1c) levels of less than 7% (intervention 60.9% vs. usual care 35.7%; P < .001) and remission of depression (PHQ-9 score of less than 5: intervention 58.7% vs. usual care 30.7%; P < .001) in comparison with patients in the usual care group at 12 weeks.

Conclusions: A randomized controlled trial of a simple, brief intervention integrating treatment of type 2 diabetes and depression was successful in improving outcomes in primary care. An integrated approach to depression and type 2 diabetes treatment may facilitate its deployment in real-world practices with competing demands for limited resources.

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Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Patient outcome of ≥80% adherence to oral hypoglycemic agent and to antidepressant medication. Note: Assessed with the Medication Event Monitoring System at baseline (preintervention) and at 6 and 12 weeks postintervention, according to treatment assignment.
Figure 2
Figure 2
Patient outcome of ≥80% adherence to oral hypoglycemic agent and to antidepressant medication. Note: Assessed with the Medication Event Monitoring System at baseline (preintervention) and at 6 and 12 weeks postintervention, according to treatment assignment.
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Comment in

References

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