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. 2012 May;20(5):452-6.
doi: 10.1097/JGP.0b013e31823e2d03.

5-HTTLPR short allele, resilience, and successful aging in older adults

Ruth OʼHara  1 , Peter Marcus, Wesley K Thompson, John Flournoy, Ipsit Vahia, Xiaoyan Lin, Joachim Hallmayer, Colin Depp, Dilip V Jeste
Affiliations

5-HTTLPR short allele, resilience, and successful aging in older adults

Ruth OʼHara et al. Am J Geriatr Psychiatry. 2012 May.

Abstract

Objective: Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults.

Methods: In a cross-sectional study of 99 healthy, community-dwelling, older adults, we determined 5-HTTLPR genotype status and administered the Connor-Davidson Resilience Scale and self-reported measures of successful aging, cognition, and health.

Results: There was no significant association between the 5-HTTLPR s allele and resilience. S allele carriers had worse cognition and self-report ratings of successful aging.

Conclusion: These findings suggest that the impact of the 5-HTTLPR s allele on stress-related outcomes may attenuate with older age. However, s allele status appears to be a biomarker of poorer self-rated successful aging, and cognitive performance in older adults.

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References

    1. Stein MB, Campbell-Sills L, Gelernter J. Genetic Variation in 5HTTLPR Is Associated with Emotional Resilience. Am J Med Genet Part B. 2009;150B:900–906. - PMC - PubMed
    1. Bonanno GA. Loss, Trauma and Human Resilience—Have We Understood the Human Capacity to Thrive After Extremely Aversive Events? Am Psychol. 2004;59:20–28. - PubMed
    1. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389. - PubMed
    1. Reichstadt J, Depp CA, Palinkas LA, Folsom DP, Jeste DV. Building Blocks of Successful Aging: A Focus Group Study of Older Adults' Perceived Contributors to Successful Aging. Am J Ger Psy. 2007;15(3):194–201. - PubMed
    1. Lamond AJ, Depp CA, Allison M, Langer R, Reichstadt J, Moore DJ, Golshan S, Ganiats TG, Jeste DV. Measurement and predictors of resilience among community-dwelling older women. J Psychiatr Res. 2008 Dec;43(2):148–54. - PMC - PubMed

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