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Review
. 2012 Sep;6(3):354-63.
doi: 10.1007/s12105-011-0327-2. Epub 2012 Jan 11.

Well-differentiated liposarcoma/atypical lipomatous tumor of the oral cavity: report of three cases and review of the literature

Evangelia Piperi  1 , Konstantinos I Tosios, Nikolaos G Nikitakis, Vasileios F Kyriakopoulos, Fotios Tzerbos, Ioannis G Koutlas, Alexandra Sklavounou
Affiliations
Review

Well-differentiated liposarcoma/atypical lipomatous tumor of the oral cavity: report of three cases and review of the literature

Evangelia Piperi et al. Head Neck Pathol. 2012 Sep.

Abstract

Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.

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Figures

Fig. 1
Fig. 1
Case 1. An unencapsulated but circumscribed cellular mass (hematoxylin-eosin, original magnification ×25)
Fig. 2
Fig. 2
Case 1. Mature adipocytes of variable size and shape in a fibrous stroma (hematoxylin-eosin, original magnification ×100)
Fig. 3
Fig. 3
Case 1. Adipocytes intermixed with cytologically bland spindle cells (hematoxylin-eosin, original magnification ×100)
Fig. 4
Fig. 4
a Case 3. Lipoblasts with marked nuclear pleomorphism and vacuolated cytoplasm. b Case 3. Signet-ring cells. c Case 1. A rare mitotic figure (hematoxylin-eosin, original magnification ×400)
Fig. 5
Fig. 5
Case 2. Small vessel and nerve infiltration by neoplastic adipocytes (hematoxylin-eosin, original magnification ×100)
Fig. 6
Fig. 6
Case 3. Infiltration of adjacent muscle fibers by neoplastic adipocytes (hematoxylin-eosin, original magnification ×100)
See this image and copyright information in PMC

References

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