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. 2011 Mar;150(5):607-9.
doi: 10.1007/s10517-011-1202-6.

In vitro study of neuroprotective properties of GK-2, a new original nerve growth factor mimetic

T A Antipova  1 , T A Gudasheva, S B Seredenin
Affiliations

In vitro study of neuroprotective properties of GK-2, a new original nerve growth factor mimetic

T A Antipova et al. Bull Exp Biol Med. 2011 Mar.

Abstract

New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10(-9)M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H(2)O(2)and glutamate. GK-2 in a concentration of 10(-8)M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.

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