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Clinical Trial
. 1990 Oct;62(4):637-42.
doi: 10.1038/bjc.1990.345.

Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis

R P Moseley  1 , A G Davies, R B Richardson, M Zalutsky, S Carrell, J Fabre, N Slack, J Bullimore, B Pizer, V Papanastassiou, et al.
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Free PMC article
Clinical Trial

Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis

R P Moseley et al. Br J Cancer. 1990 Oct.
Free PMC article

Abstract

Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). Nine patients were evaluable for either a tumour or clinical response. Six of these demonstrated an event-free response that was maintained for periods of between 7 and 26 months.

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