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Review
. 2012 Jan;30(1):48-56.
doi: 10.3109/07357907.2011.630050.

Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets

Hua Mao  1 , Drake G Lebrun, Jingxuan Yang, Vivian F Zhu, Min Li
Affiliations
Review

Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets

Hua Mao et al. Cancer Invest. 2012 Jan.

Abstract

Glioblastoma multiforme (GBM) is the most malignant and aggressive type of brain tumor with an average life expectancy of less than 15 months. This is mostly due to the highly mutated genome of GBM, which is characterized by the deregulation of many key signaling pathways involving growth, proliferation, survival, and apoptosis. It is critical to explore novel diagnostic and therapeutic strategies that target these pathways to improve the treatment of malignant glioma in the future. This review summarizes the most common and important pathways that are highly mutated or deregulated in GBM and discusses potential therapeutic strategies targeting these pathways.

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Conflict of interest statement

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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