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. 2012 Apr;129(4):1162-4.
doi: 10.1016/j.jaci.2011.11.046. Epub 2012 Jan 10.

Recurrent severe exacerbations in early life and reduced lung function at school age

Amy L O'Brian, Robert F Lemanske Jr, Michael D Evans, Ronald E Gangnon, James E Gern, Daniel J Jackson

Recurrent severe exacerbations in early life and reduced lung function at school age

Amy L O'Brian et al. J Allergy Clin Immunol. 2012 Apr.

Abstract

Severe wheezing exacerbations during the preschool years, a critical time in lung growth and development, may lead to airway damage and remodeling. Our study linked these events to a partially reversible reduction in lung function present at school age.

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Figures

Figure 1
Figure 1
Figure 1a : Pre-bronchodilator FEV0.5 & FEV1 assessed longitudinally between 5–8 years of age were significantly decreased in children with histories of recurrent (≥2) wheezing exacerbations treated with OCS when compared to children with no wheezing, mild to moderate wheezing, or 1 severe wheezing exacerbation requiring OCS. This figure demonstrates that these between group differences were stable over time. Figure 1b : Post-bronchodilator FEV0.5 & FEV1 assessed longitudinally between 6–8 years of age were not significantly different between children with histories of recurrent (≥2) severe wheezing exacerbations treated with OCS and those children with no wheezing, mild to moderate wheezing, or 1 severe exacerbation requiring OCS.
Figure 1
Figure 1
Figure 1a : Pre-bronchodilator FEV0.5 & FEV1 assessed longitudinally between 5–8 years of age were significantly decreased in children with histories of recurrent (≥2) wheezing exacerbations treated with OCS when compared to children with no wheezing, mild to moderate wheezing, or 1 severe wheezing exacerbation requiring OCS. This figure demonstrates that these between group differences were stable over time. Figure 1b : Post-bronchodilator FEV0.5 & FEV1 assessed longitudinally between 6–8 years of age were not significantly different between children with histories of recurrent (≥2) severe wheezing exacerbations treated with OCS and those children with no wheezing, mild to moderate wheezing, or 1 severe exacerbation requiring OCS.
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