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. 2012 Mar;129(3):858-860.e2.
doi: 10.1016/j.jaci.2011.12.002. Epub 2012 Jan 10.

Age-related differences in the pathogenesis of chronic rhinosinusitis

Seong H Cho, Seung J Hong, Brian Han, Sun H Lee, Lydia Suh, James Norton, David Lin, David B Conley, Rakesh Chandra, Robert C Kern, Bruce K Tan, Atsushi Kato, Anju Peters, Leslie C Grammer, Robert P Schleimer

Age-related differences in the pathogenesis of chronic rhinosinusitis

Seong H Cho et al. J Allergy Clin Immunol. 2012 Mar.
No abstract available

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Conflict of interest statement

Disclosure of potential conflict of interest: R. C. Kern and R. P. Schleimer received research support from the National Institutes of Health. The rest of the authors declare that they have no relevant conflicts of interest.

Figures

FIG 1
FIG 1
Age-related distribution of the ECP and HNE protein levels in nasal lavage fluids from normal subjects and from patients with CRS as determined by ELISA. A, In the CRSwNP subtype, ECP levels in elderly patients were significantly lower compared with those in nonelderly patients. B and C, There was a significant negative correlation between ECP levels and age in patients with CRSwNP, but not in patients with CRSsNP. D–F, The HNE levels from normal subjects and from patients with CRS were not different by age, and there was no correlation between HNE levels with aging. E, Elderly; NE, nonelderly.
FIG 2
FIG 2
Age-related distribution of the human S100A8/A9 protein levels in nasal lavage fluids from normal subjects and from patients with CRS as determined by ELISA. A, In normal controls and patients with CRSsNP, S100A8/9 levels in elderly subjects were significantly lower compared with those in nonelderly subjects. B–D, Levels of S100A8/A9 were significantly diminished with increasing age in normal controls and patients with both subtypes of CRS. E, Elderly; NE, nonelderly.
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