doi: 10.1016/j.bmcl.2011.12.054.
Epub 2011 Dec 17.
Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides
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- PMID: 22237251
- DOI: 10.1016/j.bmcl.2011.12.054
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Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides
Bioorg Med Chem Lett.
.
Abstract
Regiospecifically sulfated chondroitin sulfate repeating tetrasaccharides, CS-OO, GlcAβ-GalNAcβ-GlcAβ-GalNAcβ;CS-EE, GlcAβ-GalNAc(4S6S)β-GlcAβ-GalNAc(4S6S)β; and CS-AA, GlcAβ-GalNAc(4S)β-GlcAβ-GalNAc(4S)β, having biotin linked with a hydrophilic linker at the reducing terminal were synthesized effectively by a coupling of the corresponding disaccharide units and regioselective sulfation. CS-EE showed greater affinity for midkine than CS-AA and CS-OO.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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