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. 2012 Feb;53(2):234-40.
doi: 10.2967/jnumed.111.091694. Epub 2012 Jan 11.

Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy

Jussi Hirvonen  1 , William C Kreisl, Masahiro Fujita, Irene Dustin, Omar Khan, Shmuel Appel, Yi Zhang, Cheryl Morse, Victor W Pike, Robert B Innis, William H Theodore
Affiliations

Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy

Jussi Hirvonen et al. J Nucl Med. 2012 Feb.

Abstract

Animal studies and clinical observations suggest that epilepsy is associated with inflammation. Translocator protein (TSPO) (18 kDa), a marker of inflammation, is increased in vitro in surgical samples from patients with temporal lobe epilepsy. TSPO can be measured in the living human brain with PET and the novel radioligand (11)C-PBR28. In this study, we sought to determine whether in vivo expression of TSPO is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy.

Methods: Sixteen patients with unilateral temporal lobe epilepsy and 30 healthy subjects were studied with (11)C-PBR28 PET and MRI. Uptake of radioactivity after injection of (11)C-PBR28 was measured from regions of interest drawn bilaterally onto MR images. Brain uptake from ipsilateral and contralateral hemispheres was compared using a paired-samples t test.

Results: We found that brain uptake was higher ipsilateral to the seizure focus in the hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and choroid plexus but not in other brain regions. This asymmetry was more pronounced in patients with hippocampal sclerosis than in those without.

Conclusion: We found increased uptake of radioactivity after injection of (11)C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy, suggesting increased expression of TSPO. Studies in larger samples are required to confirm this finding and determine the clinical utility of imaging TSPO in temporal lobe epilepsy.

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Figures

FIGURE 1
FIGURE 1
Coronal sections of MR, PET, and fused PET/MR images demonstrate distribution of radioactivity in brain after injection of 11C-PBR28 in patient with left-sided temporal lobe epilepsy. PET image is summed from 0 to 120 min. Right side of brain appears on left side of image. Area within red rectangles appears magnified in bottom row. There is higher uptake in ipsilateral than in contralateral side in choroid plexus (red arrow) and hippocampus (black arrow).
FIGURE 2
FIGURE 2
Uptake of radioactivity after injection of 11C-PBR28 ipsilateral and contralateral to seizure focus in brain regions that showed significant asymmetry. Values are mean of all 16 patients.
See this image and copyright information in PMC

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