Emerging topics in epigenetics: ants, brains, and noncoding RNAs

Abstract

One of the greatest wonders in biology is the high degree of molecular organization and complexity achieved by multicellular life forms, which are typically composed by hundreds of cell types, each with a unique identity and function and all sharing the same genome. Long-term maintenance of these distinct cell identities requires epigenetic signals, molecular signatures that regulate gene expression and can be inherited during cell division. Some epigenetic signals also appear to have an intimate connection with brain function, with important implications for neuroscience and medicine. To better understand these phenomena, new technologies must be developed and nonconventional model organisms should be studied. For example, the genomes of eusocial insects, such as ants and honeybees, specify drastically different morphologies (polyphenism) and behaviors (polyethism) that yield adult individuals belonging to different castes, which carry out separate functions inside the colony. These sharp epigenetic differences present unique opportunities for the experimental dissection of molecular pathways that may be conserved in other organisms, including humans.