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. 1977 Dec;22(12):1064-8.
doi: 10.1007/BF01072858.

Effects of ethanol on electrical parameters of the in vivo rat stomach

R J Biggerstaff, G J Leitch

Effects of ethanol on electrical parameters of the in vivo rat stomach

R J Biggerstaff et al. Am J Dig Dis. 1977 Dec.

Abstract

The gastric transmural electrical potential difference (PD) and direct-current resistance were measured in the rat in vivo under conditions in which the luminal pH was controlled over the pH range 1.0 to 12.0. Raising the pH above 11.0 caused a reduction in both PD and resistance. This is consistent with basic groups limiting cation permeability through the mucosa. Exposure of the mucosa to 20% ethanol caused a reduction in resistance, PD, and H+ secretion, and an increased appearance of Na+ in the lumen at neutral pH. The pH dependence of the resistance at high pH values was also eliminated, consistent with the elimination or bypassing of channels containing basic groups. Mucosal exposure to 8.5% ethanol reduced the PD and H+ secretion without affecting resistance. The increased appearance of Na+ in the lumen seen with this alcohol solution also occurred following exposure to hyperosmotic sucrose.

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References

    1. Life Sci. 1975 May 15;16(10):1513-20 - PubMed
    1. Am J Dig Dis. 1974 Sep;19(9):818-24 - PubMed
    1. Proc Soc Exp Biol Med. 1967 Dec;126(3):657-62 - PubMed
    1. Am J Physiol. 1947 Apr;149(1):162-76 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3731-4 - PubMed