The impact of omega-3 fatty acids on depressive disorders and suicidality: can we reconcile 2 studies with seemingly contradictory results?
- PMID: 22244020
- PMCID: PMC3735441
- DOI: 10.4088/JCP.11com07463
The impact of omega-3 fatty acids on depressive disorders and suicidality: can we reconcile 2 studies with seemingly contradictory results?
Comment on
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Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry.J Clin Psychiatry. 2006 Dec;67(12):1954-67. doi: 10.4088/jcp.v67n1217. J Clin Psychiatry. 2006. PMID: 17194275 Review.
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A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids.J Clin Psychiatry. 2007 Jul;68(7):1056-61. doi: 10.4088/jcp.v68n0712. J Clin Psychiatry. 2007. PMID: 17685742
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A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder.J Clin Psychiatry. 2009 Dec;70(12):1636-44. doi: 10.4088/JCP.08m04603. Epub 2009 Aug 25. J Clin Psychiatry. 2009. PMID: 19709502 Free PMC article. Clinical Trial.
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Complementary and alternative medicine for major depressive disorder: a meta-analysis of patient characteristics, placebo-response rates, and treatment outcomes relative to standard antidepressants.J Clin Psychiatry. 2010 Jun;71(6):682-8. doi: 10.4088/JCP.10r05976blu. J Clin Psychiatry. 2010. PMID: 20573327
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Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression.J Clin Psychiatry. 2012 Jan;73(1):81-6. doi: 10.4088/JCP.10r06710. Epub 2011 Aug 9. J Clin Psychiatry. 2012. PMID: 21903025
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Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison.J Clin Psychiatry. 2011 Dec;72(12):1585-90. doi: 10.4088/JCP.11m06879. Epub 2011 Aug 23. J Clin Psychiatry. 2011. PMID: 21903029 Free PMC article.
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Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression.J Clin Psychiatry. 2011 Dec;72(12):1577-84. doi: 10.4088/JCP.10m06634. Epub 2011 Sep 6. J Clin Psychiatry. 2011. PMID: 21939614 Free PMC article.
References
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- Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry. 1999 May;56(5):407–12. - PubMed
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- Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE, Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL. Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry. 2006 Dec;67(12):1954–67. Review. Erratum in: J Clin Psychiatry. 2007 Feb;68(2):338. - PubMed
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- Wozniak J, Biederman J, Mick E, Waxmonsky J, Hantsoo L, Best C, Cluette-Brown JE, Laposata M. Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial. Eur Neuropsychopharmacol. 2007 May-Jun;17(6–7):440–7. - PubMed
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