Comment
doi: 10.1016/j.molcel.2011.12.023.
Cysteine 38 holds the key to NF-κB activation
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- PMID: 22244324
- DOI: 10.1016/j.molcel.2011.12.023
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Comment
Cysteine 38 holds the key to NF-κB activation
Mol Cell.
.
Free article
Abstract
The importance of parallel signaling pathways controlling NF-κB subunit posttranslational modifications is demonstrated by Sen et al. (2012), who reveal that RelA (p65) sulfhydration, at its highly conserved cysteine 38 residue, regulates association with the coactivator RPS3, DNA binding, and antiapoptotic gene expression.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions.Mol Cell. 2012 Jan 13;45(1):13-24. doi: 10.1016/j.molcel.2011.10.021. Mol Cell. 2012. PMID: 22244329 Free PMC article.
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