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Comment
. 2012 Jan 13;45(1):3-5.
doi: 10.1016/j.molcel.2011.12.016.

Get back TFIIF, don't let me Gdown1

Joaquín M Espinosa  1
Affiliations
Comment

Get back TFIIF, don't let me Gdown1

Joaquín M Espinosa. Mol Cell. .

Abstract

In this issue of Molecular Cell, papers by the Price and Roeder labs reveal how the Gdown1 protein antagonizes the general transcription factor TFIIF during RNAPII initiation and elongation and how the Mediator complex intervenes in this molecular tug-of-war to activate RNAPII.

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Figures

Figure
Figure
Gdown1 antagonizes TFIIF during both PIC formation and elongation, thus creating poised and stably paused forms of RNAPII, respectively. The Mediator complex is required to activate transcription in the presence of Gdown1. Mediator helps RNAPII escape poised and paused states by favoring TFIIF inclusion and/or recruiting P-TEFb.
See this image and copyright information in PMC

Comment on

References

    1. Bernecky C, Grob P, Ebmeier CC, Nogales E, Taatjes DJ. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biol. 2011;9:e1000603. - PMC - PubMed
    1. Cheng B, Price DH. Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. J Biol Chem. 2007;282:21901–21912. - PubMed
    1. Cheng, et al. Mol Cell. THIS ISSUE.
    1. Hu X, Malik S, Negroiu CC, Hubbard K, Velalar CN, Hampton B, Grosu D, Catalano J, Roeder RG, Gnatt A. A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A. 2006;103:9506–9511. - PMC - PubMed
    1. Jishage, et al. Mol Cell. THIS ISSUE.

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