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Review
. 2012 Apr;59(4):569-76.
doi: 10.1053/j.ajkd.2011.11.035. Epub 2012 Jan 11.

Dosing of renal replacement therapy in acute kidney injury

Anitha Vijayan  1 , Paul M Palevsky
Affiliations
Review

Dosing of renal replacement therapy in acute kidney injury

Anitha Vijayan et al. Am J Kidney Dis. 2012 Apr.

Abstract

The impact of the intensity of renal replacement therapy on outcomes in patients with acute kidney injury has been studied intensively during the past decade. In this review, we consider the concept of dose of renal replacement therapy in acute kidney injury and summarize the recent clinical trials addressing this topic. Although several single-center trials suggest that more intensive therapy is associated with improved outcomes, 2 large multicenter randomized trials do not find a benefit with higher doses of therapy. Based on these studies, we provide recommendations for the delivered intensity of renal replacement therapy in acute kidney injury.

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Figures

Figure 1
Figure 1
Conceptual illustration of survival in AKI: Survival increases with increasing doses of RRT, until an inflection point (arrow), after which further increases in dose do not affect outcome. Modified with permission from Palevsky et al.
See this image and copyright information in PMC

Comment in

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