Agonist trigger: what is the best approach? Agonist trigger with aggressive luteal support

Abstract

Although gonadotropin-releasing hormone agonist (GnRHa) trigger is effective in the prevention of ovarian hyperstimulation syndrome, lower conception rates have been reported. Intensive luteal phase support is an effective approach to improve implantation rates in women with peak E(2) levels ≥ 4,000 pg/mL. However, patients with peak E(2) levels <4,000 pg/mL may require a dual trigger with GnRHa and 1,000 IU hCG and intensive luteal phase support to improve implantation rates.